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Kayshild (semaglutide) EPAR Risk Management Plan (thyroid C-cell tumours in rodents)

Compared with extreme, difficult-to-follow diets, this medication is an excellent tool for reaching an ideal weight without feeling like you are dieting. Still, we work closely with our weight loss patients to help them establish a long-term, sustainable, and healthy diet and lifestyle that supports their well-being and confidence

Semaglutide slows gastric emptying, the speed at which food leaves your stomach

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Additionally, GLP-1 delays gastric emptying and leads to gut distension (an expansion of the gut)

Abbreviations GalN: D-galactosamine GP: Glutathione peroxidase GR: Glutathione reductase GSH: Reduced glutathione GSSG: Oxidized glutathione GCS: -glutamylcysteine synthetase GCS-HS: Catalytic (heavy) subunit of-glutamylcysteine synthetase GCS-LS: Regulatory (light) subunit of-glutamylcysteine synthetase SOD: Superoxide dismutase IL-6: Interleukin-6 STAT3: Signal transducer and activator of transcription 3 TNF-: Tumor necrosis factor- NF-B: Nuclear factor kappa B GOT: Glutamic oxaloacetic transaminase GPT: Glutamic pyruvic transaminase ROS: Reactive oxygen species NOS: Nitric oxide synthase G6PD: Glucose-6-phosphate dehydrogenase 6PGD: 6-phosphogluconate dehyderogenase HMP: Hexose monophosphate pathway References Akerboom TP, Bilzer M, Sies H (1982) The relationship of biliary glutathione disulfide efflux and intracellular glutathione disulfide content in perfused rat liver