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Rocio Salas-Whalen explains, obesity and weight gain are multifactorial, and GLP-1s can only tackle one piece of the puzzle
As the 16-methyl analogue of cortisol, it possesses roughly 25-fold greater anti-inflammatory potency yet virtually no mineralocorticoid activity, allowing clinicians to achieve strong glucocorticoid effects without problematic sodium retention
doi: 10.1073/pnas.1202870109 100 IfrimDCQuintinJJoostenLAJacobsCJansenTJacobsLet al
The primary goal here is tolerability, not maximum weight loss
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