In line with this vital role in mitochondrial defense, Gpx4 null mice die during early embryonic development, while Gpx4 + / - cells are sensitive to oxidative stress triggers (Legault et al., 2000
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The cells were seeded in 96-well plates at a density of 5 10 4 cells/well and incubated with varying concentrations (100, 1000, and 10,000 M) of the compounds for 2, 4, and 6 h
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