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The patients who succeed on Rybelsus share common characteristics: they have structured morning routines, baseline A1C between 7.5% and 9.0%, strong medication adherence history, and realistic expectations about weight loss (5 to 10 pounds, not 30 to 50 pounds)
This is because OCD subtypes arent separate diagnoses, but categories of different types of OCD obsessions and compulsions
Importantly, analysis of a recently published data set from single-cell RNA sequencing of mucosal biopsies from CD patients (35), confirmed the human relevance of these findings
One resulting mutation, Glu72Arg, emerged as especially promising because it lies near the scissile bond (Supplementary Tables 4 and 5)