stacking tirzepatide and semaglutide vs Semaglutide: Key Differences Explained Retatrutide + Cagrilintide Benefits: 4

"Novo Nordisk says stopping obesity drug may cause full weight regain in 5 years"

Mao D, Cao H, Shi M, Wang CC, Kwong J, Li JJ, et al

Tirzepatide acts on both GLP-1 and another hormone called GIP (glucose-dependent insulinotropic polypeptide)

FIGURE 2: FDA-APPROVED GLP-1 RA MEDICATIONS Source: FDA-approved labeling for each medication (as of March 2025) You can calculate your BMI from height and weight using this online BMI calculator [archived link]

GIP, or glucose-dependent insulinotropic polypeptide, is another gut hormone that: Stimulates insulin release Supports fat metabolism May contribute to enhanced weight loss when paired with GLP-1 By acting on both pathways, tirzepatide delivers a synergistic effect that may produce greater results than GLP-1 alone

So, while they can work, they also carry a higher risk of inconsistency in dosing, potency, or formulation