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Tsai EC, Matsumoto AM, Fujimoto WY, Boyko EJ
Hexarelin's broader impact makes it relevant for studies examining rapid GH elevation and cardiovascular function, while sermorelin's controlled approach suits research focused on maintaining physiological hormone patterns
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Its potential benefit has been posited due to its effect on improving mitochondrial function and the benefit seen as a neuroprotective agent in other clinical situations such as ischemic stroke, neurodegenerative diseases, and chemotherapy-induced encephalopathy.13 The authors of one article posited 2-3mg/kg/day divided into three doses for 7-10 days for newly infected patients could be a reasonable dose for initial studies.14 Given one meta-analysis reported that 12-35% of patients with long COVID suffered from cognitive impairment (colloquially called brain fog) and another found elevated brain injury markers during the acute phase of COVID-19, potential treatment and management strategies are in demand.13,14,15 Currently there are some trials evaluating the use of methylene blue for COVID-19, though, results and outcomes are not yet available.16,17 Brain injury and traumatic brain injury continue to be significant sources of morbidity and mortality and effective treatment options for prevention of acute and long-term damage are needed
Reviews of the wider class note that GHS effects are generally not fully specific for GH, with prolactin, ACTH and cortisol responses documented across the family [12]
