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Owing to their effectiveness in reducing body weight, once-daily subcutaneous administration of liraglutide 3.0 mg has been approved, and once-weekly subcutaneous administration of semaglutide 2.4 mg is being investigated in phase III trials, for obesity management

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The liver specific ACLY inhibitor bempedoic acid is FDA approved for LDL cholesterol lowering 3,39 , and the first ACSS2 inhibitor has entered oncology clinical trials (NCT04990739)

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