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During obesity-induced adipose tissue remodeling, abnormal secretion of proinflammatory factors and adipokines promotes tumor cell proliferation, invasion, and metastasis, accelerating tumor progression
Mishra R et al
Some other possible side effects that may occur include: Headache Stomach pain Fatigue Constipation Dizziness Heartburn or indigestion Low blood sugar (hypoglycemia) Bloating Gas Mood changes Although rare, they can rarely cause serious and sometimes life-threatening adverse effects such as: Severe allergic reaction Pancreatitis Gallstones Kidney problems Worsening vision (diabetic retinopathy) in type 2 diabetics Heart rate changes Suicidal thoughts or behaviors Increased risk of thyroid cancer Bowel obstruction (a blockage that keeps food from passing through your intestines) These are not all of the possible adverse effects of these medications
The drop in LDL cholesterol was assumed to be insignificant in clinical terms
(2003b)
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