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This becomes particularly relevant in the context of GLP-1 receptor agonist therapy, where the substantial weight loss these medications produce is not exclusively fat loss

TRT and GLP-1 medications have been shown to lower inflammatory markers, leading to better overall metabolic health

[11] This isn't just laboratory curiosity, it represents real functional advantages

Another treatment is PT-141

Limitations Several limitations of this study should be acknowledged

The gross-to-net bubble keeps inflating: Rebates cut list prices roughly in half Patients cover ~22% of net costs Insurers capture ~90% of rebate value Despite higher list prices, the actual net cost per GLP-1 prescription has stayed flat