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it depletes GSH indirectly through oxidation, and enzyme activity may decline secondarily (~35% in some studies), but this is not the primary cause. Option (D): Primaquine decreases reduced glutathione levels by promoting its oxidation to combat ROS, not increases them. Introduction: Unraveling Primaquine Hemolytic Anemia and NADPH Demand Primaquine hemolytic anemia strikes G6PD-deficient patients when the drugs metabolites spike NADPH demand for antioxidant protection
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Discussion To the extent of our knowledge, this is the first study to quantify brain GSH, using a validated MRS method (53), and explore relationships between peripheral MMPs, TIMPs, and MPO in participants with PTSD and HC
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