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Septerna has developed a native complex platform that can reconstitute the GLP-1 receptor within an artificial lipid bilayer, complexed with combinations of drug and internal cell signalling molecules, which replicates the dynamics of the signalling process at scale
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As replacements that 'mimic' or 'boost' GLP-1 on their own, the effect is far weaker than the medication and the big claims are mostly marketing
And I think that's a hope that's not often offered to people
Lin et al., 2021)
Benefits & How It Works is a useful companion read
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