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The amounts used topically or in injectable protocols are tiny compared to dietary copper intake

its function depends on the ATP-driven chaperone cycle and requires cooperation with HSP40 co-chaperones and nucleotide exchange factors (NEFs), which regulate substrate binding and release, promote correct protein folding, and prevent protein aggregation (Maugeri et al., 2010)

This synergy forms the basis of advanced regenerative research blends focused on recovery, skin health, and post-injury repair

2013;305(12):E1444-51

When treated with 5FU, cancer cells specifically increase mitochondrial content to buffer nucleotide stress, whereas stromal cells do not, meaning that cancer cells become intrinsically more dependent on mitochondrial metabolism

Some users mention sensitivity to vitamin E as a concern, causing occasional breakouts