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In other biological matrices, such as liver S9 fraction or liver homogenate, kidney S9 fraction or kidney homogenate, plasma, and tumor cells, in vitro stability studies or metabolite identification studies can also be performed (Figure 15)

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COP1 dimerizes through its coiled-coil domain, allowing another COP1 (COP1 WD40a ), which further interacts with a separate DDD-E2 complex in a similar manner, to associate with blades V-VI of DET1 (Fig