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The routine is the challenge

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and Ba, J

2015 (5) CD010012

While we cannot rule out that the differences in the conformation of the middle loop may come from crystal packing constraints or the allosteric effects from binding to GPCRs 24,25,26,27 , it is tempting to speculate that the larger conformational changes in -strand V upon Src SH3 binding might affect the coupling of arr1 to the receptor and the downstream signaling

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