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Succinate dehydrogenase (SDHA), which is associated with 14 under-represented proteins, is also involved in energy metabolism

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In addition, combined investigations using human HSCR samples and endothelin receptor B-deficient mice have demonstrated impaired epithelial regeneration and disrupted stromal-epithelial signaling, characterized by depletion of LGR5 stem cells and a shift toward proinflammatory stromal populations, which may contribute to Hirschsprung-associated enterocolitis 136

Romero L, Andrews K, Ng L, ORourke K, Maslen A, Kirby G

3D Synthetic peptide-based architectures for the engineering of the enteric nervous system