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A nationwide Danish retrospective cohort study indicated that GLP-1 RAs may offer protection against lower extremity amputations in patients with T2DM, compared to sulfonylureas [98]

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While semaglutide's single-pathway mechanism may produce slightly less aggressive weight loss than tirzepatide over time, many patients maintain their progress and continue losing weight on semaglutideespecially if side effects were limiting their adherence on tirzepatide

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