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J Phys Chem B (2019) 123:1036575
FDA briefing documents released before the meeting proposed the same conclusion for all seven peptides: do not add them
Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
These peptides create pulsatile growth hormone release mimicking natural patterns without elevating cortisol or prolactin
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Christopher S
