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Clinically meaningful weight loss, defined as at least 5% of starting body weight, typically appears between weeks 12 and 16 for patients who reach the 1.0 mg or 1.7 mg maintenance step

Some users reduce their total weekly dose during microdosing, which may stretch supply but could compromise efficacy

Larger, longer-duration trials with robust outcome measures are needed to determine whether these medications can meaningfully alter the course of Parkinson's disease or improve quality of life for patients

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