Pro-inflammatory cytokines are associated with several diseases such as renal disease, 3 obesity, 4 and inflammatory bowel disease
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4 synthesis, and dihydrofolate reductase, the enzyme that recycles BH 2 to BH 4 , further contributes to eNOS uncoupling in diabetes and hypercholesterolemia (Xu et al., 2009
The amount of chemicals we are exposed to daily is astronomical