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However, the regulatory framework for drug development relies heavily on animal toxicology precisely because it does provide meaningful safety signals
Compared to solution formulas, the lyophilized powder structure is more stable over time
And the RDA, the government recommended amount of thiamine to get, is around 1.3 milligrams
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Subcutaneous injection provides near 100% bioavailability and systemic distribution, whereas topical application is limited by skin barrier penetration
They are not interchangeable dose-for-dose
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