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Heatwole CR, Eichinger KJ, Friedman DI, Hilbert JE, Jackson CE, Logigian EL, Martens WB, McDermott MP, Pandya SK, Quinn C: Open-label trial of recombinant human insulin-like growth factor 1/recombinant human insulin-like growth factor binding protein 3 in myotonic dystrophy type 1

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Notably, 4-OI has been shown to protect osteoblasts from H 2 O 2 -induced oxidative damage by activating the Nrf2 pathway [47]

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But further research is needed to confirm these findings in clinical trials

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