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Triggered by upstream signals, the initiator caspases undergo autocleavage, and the subsequently activated cleaved initiator caspases stimulate the downstream executioner caspases to execute apoptosis (106)
In the rotenone group, LC3-II expression was significantly decreased compared to the vehicle-injected control
Oltval ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death