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High doses of acetaminophen (Tylenol) rapidly deplete the liver's glutathione reserves, so taking them concurrently can alter drug metabolism

Effects in active malignancy are not well characterized, and most clinicians treat this as an exclusion until more data exists

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However, specific chemotherapeutic agents can induce immunogenic cell death (ICD), characterized by the release of damage-associated molecular patterns (DAMPs) that prime antitumor T cell responses (43, 44)

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