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A 2024 npj Aging paper (doi:10.1038/s41514-024-00160-6) demonstrated that adiponectin receptor expression on B cells declines with age, reducing endogenous PEPITEM levels and allowing progressive T-cell infiltration of metabolically active tissues a direct molecular mechanism for inflammaging

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These subsets range from diverse epithelial cells and myeloid cell types, such as tissue-resident macrophages and dendritic cell (DC) subclasses, to lymphoid subpopulations with distinct functions and increasingly complex characteristics

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