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Increased Epididymal levels of glutathione (GSH) (part of the male reproductive tract, where sperm final maturation occurs) can protect the sperm membrane PUFA, playing a protective role in sperm maturation

maintenance phase is the heavy draw 26 weeks 13 vials Standard Phase 2 duration 32 weeks 16 vials Phase 2 T2D study duration 68 weeks 30 vials REDEFINE 1 / REDEFINE 2 endpoint duration Peptide Vials (10 mg vial, 2.4 mg/week target) Each 10 mg vial covers about 4 weekly doses at 2.4 mg/week

2021;doi:10.1001/jamacardio.2021.5083 Shapiro MD, Fazio S

Biol Reprod 86:110

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2 This coupling has a subtle implication for the durability question