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doi: 10.3389/fmicb.2015.01543 61 FranklinH.ClarkeB

2018 May;22(2):325-346

Scientists dont exactly know why this reaction happens but suspect that one reason is that the killed spirochetes break down and release toxins, and our immune systems response to this spill is what causes the symptoms of the Jarisch Herxheimer reaction

Daily application at roughly the same time produces better results than sporadic use even at higher doses

Glutathione improves skin tone, defends against oxidative stress (thus minimizing aging signs like wrinkles), stimulates collagen synthesis, and alleviates redness and inflammation, for a calmer, healthier complexion

"Partition and turnover of glutathione reductase from Saccharomyces cerevisiae: a proteomic approach" (PDF)