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Treating obesity with behavior change, generic anti-obesity medications, and GLP-1 seems to reduce the risk profile associated with all of these [cardiometabolic] diseases, Frank added

If a medication isn't working after 6-8 weeks at an adequate dose, your doctor may suggest switching to a different drug or adding a second medication

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For someone weighing 100kg, thats 15-25kg, significantly more than the 5-10% typically achieved with diet and exercise alone