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Adv Drug Deliv Rev 60(6):625637 Prakash J, Chouhan S, Yadav SK, Westfall S, Rai SN, Singh SP (2014a) Withania somnifera alleviates Parkinsonian phenotypes by inhibiting apoptotic pathways in dopaminergic neurons
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Zhou F, Zhang H, Cong Z, et al
doi:10.1177/2045125312436573
It is a dimeric complex composed of: The calcitonin receptor (CTR) , a GPCR The RAMP protein (Receptor Activity Modifying Protein), 1, 2 or 3 Depending on the type of RAMP, three different amylin receptors arise: AMY1 : CTR + RAMP1, primarily in the CNS (area postrema, hypothalamus) AMY2 : CTR + RAMP2, peripheral tissues AMY3 : CTR + RAMP3, bone tissue, some CNS Cagrilintide activates all three amylin receptors , but the primary therapeutic effect is via AMY1 in the area postrema (brainstem, where nausea and satiety signals are processed)
CohenJZiyyatANaouraIChabbert-BuffetNAractingiSDaraiEet al
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