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Peptide-activated GLP-1R traffics to vesicles and the Golgi apparatus Once activated, agonist-bound GLP-1R is known to leave the plasma membrane through endocytosis resulting in receptor recycling or degradation 27

Because gastrointestinal discomfort, especially nausea is a common side effect of GLP-1 receptor agonists, this formulation is specifically compounded with a low dose of ondansetron, an anti-nausea medication

While GLP-1R agonists have demonstrated cardiovascular benefits in clinical trials, including reduced rates of major adverse cardiovascular events (MACE) in T2DM patients, their antithrombotic efficacy is generally considered less potent than that of traditional antithrombotic agents

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Side effect profile differences Sublingual drops tend to produce milder GI side effects compared to injections, particularly during the dose escalation phase

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