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At these high doses, a small but consistent percentage of B12 is absorbed by passive diffusion, bypassing the intrinsic factor mechanism
Effect of methylation and mutagenesis of lysine [PMID: 3003072] Laboratory literature summary: Trimethyllysine and protein function
This risk is unquantified but mechanistically plausible and is not discussed on most vendor pages
Simple exercises like towel stretches, wall stretches, and frozen water bottle rolls can be performed multiple times daily with minimal time investment
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