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This antitumor effect was associated with a shift toward an immunostimulatory tumor-associated macrophage (TAM) phenotype and an enhanced effector T cell response within the tumor microenvironment, mediated by activation of the type I Interferon pathway (238)

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[245] [247] CYP2D6, dopamine -hydroxylase (DBH), flavin-containing monooxygenase 3 (FMO3), butyrate-CoA ligase (XM-ligase), and glycine N -acyltransferase (GLYAT) are the enzymes known to metabolize amphetamine or its metabolites in humans

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