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Presented for research literature review only Di Pietro G et al

There is evidence that Nrf2 loses its DNA binding to ARE, and that loss of Nrf2/ARE binding may be reversible by an Nrf2 agonist such as -lipoic acid 13

The pathogenesis of PRP is primarily attributed to the dysregulation of immune function of epidermal keratinocytes, with only sparse lymphocytic infiltration observed around superficial dermal blood vessels in the uppermost dermis 6,7

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