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Specifically, MSC- Igf1r / mice had less trabecular bone as defined by a significant decrease in the percent of bone volume per tissue volume (BV/TV) ( P =0.01) and trabecular thickness (Tb.Th) ( P =0.002) relative to their wt littermates (Figure 4B)
Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling
In a clinical investigation involving knee OA patients, the efficacy of PH-797804 was compared to naproxen, however the findings have not yet been released (NCT01102660)
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Other upregulated antioxidants included perilipin 5 (1.39-fold, p=0.008)), which has been shown to optimize ATP generation efficiency by regulating the oxidation of fatty acids
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