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Tirzepatides dual GIP/GLP-1 receptor mechanism produces greater weight loss and HbA1c reductions, as confirmed by SURMOUNT-5 and supported by the 2026 EASO pharmacotherapy update [1][10]

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Inhibition of glucagon secretion or antagonism of glucagon receptors has become a potentially effective treatment strategy for T2DM patients (Lund et al., 2014)