doi: 10.1056/NEJMoa1901118 55 RosenstockJAllisonDBirkenfeldALBlicherTMDeenadayalanSJacobsenJBet al
For example, Wegovy (semaglutide) Typical Dosing Both weight loss medications are given as weekly injectable doses, but their dosage amounts differ
Starting weight loss therapy with uncontrolled hypothyroidism may: Confound assessment of treatment efficacy Complicate symptom attribution (fatigue, constipation overlap) Necessitate multiple medication adjustments simultaneously Practically speaking, patients may benefit from demonstrating stable thyroid function on consistent levothyroxine dosing before adding weight loss medications, though this is not a strict requirement
For diabetes management, reassessment is appropriate if A1c targets are not achieved after 36 months of therapy
The review also notes that GLP-1 medicines reduce complications in conditions such as obstructive sleep apnea (OSA), expanding their cardiometabolic relevance
doi:10.1152/physrev.00034.2006 9