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In biochemical and cellular systems MT-II acts as a broad, non-selective agonist across the melanocortin receptor family MC1R, MC3R, MC4R and MC5R with negligible activity at MC2R
These effects seem to be mediated by GLUT4, which triggers PI3K/PKB, and glucose, which inhibits the LKB1/AMPK pathway
The Arginine Salt form further enhances its stability during digestion and potentially improves its delivery through the gut lining, ensuring its presence in systemic circulation
This self-perpetuating loop drains the cells glutathione reserves, as the antioxidant is rapidly consumed in a desperate attempt to neutralize the surging ROS
Polish J Surg (2020) 92:15
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