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The STEP trials evaluated semaglutide and showed average weight reductions of around 15% over 68 weeks, while SURMOUNT trialsfocusing on tirzepatide, a dual GIP/GLP-1 receptor agonistdemonstrated even greater reductions, with participants losing up to 21% of their body weight over 72 weeks (Note: GIP = Glucose-dependent insulinotropic polypeptide)
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The result of this effort was semaglutide
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