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Reported Side Effects (Typically Rare and Mild) Temporary lethargy or slight fatigue

Anxiety disorders are the most common mental health condition in the United States, and they often show up with physical symptoms such as muscle tension, fatigue, and trouble concentrating, as the National Institute of Mental Health explains in its overview of anxiety disorders

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Potential risks include growth hormone's counter-regulatory effects on glucose metabolism that may oppose tirzepatide's benefits, additive gastrointestinal symptoms, and growth hormone-related adverse effects such as edema and joint pain