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To encourage mating, bedding (wood shavings) used by the males was placed in the females cages

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The World Health Organization's December 2025 guidelines emphasized the importance of resistance training to protect muscle mass during GLP-1 therapy, acknowledging this as a limitation of current treatment approaches [49]

For women of reproductive age with PCOS, the priority is to simultaneously strengthen fertility planning and contraceptive management while improving ovulatory opportunities, ensuring weight and metabolic stability during the preconception washout period to avoid the maternal-fetal risks associated with a weight lossrebound cycle (133, 137)