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Throughout the experiment, animals were maintained under anaesthesia, and artificial cerebrospinal fluid (NaH 2 PO 4 2.0 mM, MgCl 2 1.0 mM, CaCl 2 1.2 mM, KCl 2.7 mM and NaCl 145 mM) was constantly pumped through the microdialysis probe at a rate of 0.5 L/min

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Nocturne G, Pontarini E, Bombardieri M, Mariette X

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Week 5-8 (dose escalation through 5 mg to 7.5 mg): Each dose increase can temporarily reintroduce body aches, particularly in the 48-72 hours following the new dose

After its first use, you can store it at a controlled room temperature (59F to 86F) or refrigerated (36F to 46F) for 56 days