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The FDA has never approved this combination, and clinical literature documenting its safety is essentially nonexistent
This absence of data is itself clinically significant it means that any combined use would occur without a formal safety profile for this specific pairing
This is because the molecule is broken down in the small intestine and the individual components then reach the liver via the bloodstream
In addition, epidemiological studies have demonstrated that patients with Type 2 diabetes who used GLP-1 RAs were less likely to be diagnosed with nicotine misuse compared to those who used other medicines for Type 2 diabetes
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Retrieved 22 December 2007
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