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If combined oral contraceptives are considered for heavy bleeding, women should be advised about the potential for reduced efficacy and the need for additional contraceptive precautions

Ignatiuk V, Izvolskaia M, Sharova V, Zakharova L

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A 2023 meta-analysis of 11 randomized controlled trials, involving 840 participants, revealed that these medications increased natural pregnancy rates by 1.72 times and improved menstrual regularity, with a standardized mean difference of 1.72

Clinical studies show that most patients lose between 510% of baseline body weight within 12 weeks, though some notice changes as early as week one

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