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Proteins with a fold change (FC) 1.5 or FC 0.6667, coupled with a P -value 0.05, were defined as significantly differential proteins (DEPs)

In SURPASS-2, a head-to-head in T2D patients, tirzepatide 15 mg produced 11.2 kg weight loss versus 5.7 kg on semaglutide 1 mg (the T2D dose at the time, not the 2.4 mg obesity dose)

This may include nausea, vomiting, diarrhea, dyspepsia, and constipation

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Most patients notice increased recovery and strength within 2-3 weeks

Tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis