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An anti-asct2 monoclonal antibody suppresses gastric cancer growth by inducing oxidative stress and antibody dependent cellular toxicity in preclinical models

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The enterocyte FXR is the sensor of luminal bile acids and increases the secretion of the enterohormone fibroblast growth factor 19 (FGF19), which regulates liver bile acid synthesis, systemic glucose metabolism, and gallbladder motility (refilling) by activation of its receptor -klothoFGFR4 [28, 31]