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Cardiovascular or respiratory disease, renal or hepatic impairment, diabetes, Helicobacter pylori infection, rheumatoid arthritis, and hypertension are also associated with increased risk

32 The SOUL trial evaluated oral semaglutide in patients with T2D who had established atherosclerotic cardiovascular disease, chronic kidney disease (CKD), or both

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PMID: 25278975 Nass R, et al

Since orally administered semaglutide absorption depends on localized SNAC buffering, co-administration with other agents has the potential for drugdrug interactions