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Effect of liraglutide, a glucagon-like peptide-1 analogue, on left ventricular function in stable chronic heart failure patients with and without diabetes (LIVE)a multicentre, double-blind, randomised, placebo-controlled trial
Any potential transdiagnostic benefit of GLP-1RAs may be amplified by their established effects on cardiovascular and metabolic morbidity and mortality 21,22 , which are known to be raised in several cognitive and mental health disorders 244,245
Redox signaling mediated by thioredoxin and glutathione systems in the central nervous system
GLP-1 receptor agonists pass the bloodbrain barrier and directly engage with GLP-1 receptors in essential appetite-regulating sites of the hypothalamus and brainstem (Trapp and Brierley 2022)
It may result in many of the same symptoms as a food allergy, but the causes are different
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