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Expiration Dating and National Drug Code Rules
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However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]
This decision removed the legal basis for most compounding pharmacies to continue producing tirzepatide
Explosive demand, and the resulting shortage of the drugs, led the FDA to allow compounding pharmacies to make and sell semaglutide and tirzepatide, which were then sold at a discounted rate, for the past several years
