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doi:10.1016/s0031-9384(02)00665-0

Clinically, treatment with metformin significantly lowers 11-dehydro-thromboxane B 2 (11-dhTxB 2 ) levels and mean platelet volume (MPV), indicating a reduction in platelet activation ( Sulfonylureas have demonstrated a reduction in ADP-induced platelet adhesiveness and platelet aggregation in preclinical studies (Klaff et al., 1981

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However, considering the intricate nature of regulating the OSR, it is probable that other signal transduction systems are involved in this regulatory network