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Retatrutide (research grade), also designated LY3437943, is a long-acting synthetic peptide engineered to co-engage three distinct G-protein-coupled receptors: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

Clinical Results Clinical trials have shown that patients using tirzepatide experienced greater average weight loss compared to semaglutide usersespecially when paired with lifestyle adjustments

That said, side effects can occur: Common side effects (mild and transient) Injection site reactions: Redness, mild swelling, or tenderness at injection sites

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