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3 Initially approved by the FDA for diabetes treatment, semaglutide (Wegovy for weight loss) and tirzepatide (Zepbound for weight loss) have expanded into broader use

There is an increasing focus on the potential contributory mechanistic role of the gut microbiota in the metabolic effects of glucoregulatory and weight loss promoting drugs, including glucagon-like peptide-1 (GLP-1) receptor agonists, which have become well-established therapies in type 2 diabetes and obesity 16,17

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Tempesta E, Casella L, Pirrongelli C, Janiri L, Calvani M, Ancona L